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Depression & Mood Disorders

More than sadness

Covering both common depressive experiences and clinically complex mood disorders — what they feel like, how they are diagnosed, and what treatment actually involves.

Leading cause of disability
Affects function, not just mood
Treatment works
Men present differently

Depression can affect concentration, sleep, appetite, energy, self-worth and a person’s ability to function — not merely mood.

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12 guides

Tap any guide to read what it covers, what to look out for and what to do next.

Sadness is a normal response to loss, disappointment or a bad stretch of life. Depression is different: it is persistent, it removes pleasure and interest, and it interferes with how you function.

  • Duration and function are the two tests — more than two weeks, most days, with real impact on daily life.
  • Depression often includes a loss of interest or pleasure, not just low mood.
  • Sadness usually comes in waves and can be interrupted; depression tends to be continuous and flat.

When to Seek Help

  • Low mood or loss of interest has lasted two weeks or more, most days.
  • You are sleeping badly, eating differently or unable to concentrate.
  • Work, study or relationships are being affected.
  • You have thoughts of harming yourself or ending your life — seek help today.

Medical review: Mental health content on HealthLab is written to be read alongside professional care, not instead of it. It is educational information only and cannot replace an assessment by a registered practitioner.

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Depression and Mood Disorders: Symptoms, Diagnosis and Treatment in South Africa

Depression is one of the leading causes of disability worldwide, and it is far more than sadness. The core features are a persistent low mood or a loss of interest and pleasure in things that used to matter, present most days for at least two weeks and severe enough to interfere with daily life. What most people do not realise is how many of the defining symptoms are invisible: irritability, indecision, a foggy slowed mind, unexplained aches and headaches, and changes in sleep and appetite. Depression is a whole-body illness, and it can be present in someone who is holding down a job, raising children and appearing entirely fine to everyone around them.

Depression looks different depending on who has it. In men it frequently presents as anger, irritability, risk-taking, overwork and alcohol use rather than visible sadness — which is a large part of why men are diagnosed less often and die by suicide more often. In women, risk shifts with hormonal and life-stage transitions: puberty, the premenstrual phase, postpartum and perimenopause, alongside drivers such as caregiving load, gender-based violence and financial strain. Bipolar disorder is a separate condition involving episodes of depression and abnormally elevated mood, and it is commonly missed because people seek help during the depressed phase only. Depression that is severe, early-onset or unresponsive to antidepressants should always prompt a check for it.

Treatment is stepped and effective. Mild depression usually responds to talking therapy and structured lifestyle change — sleep, movement, routine and reduced alcohol. Moderate to severe depression generally needs therapy and medication together, with antidepressants taking two to four weeks to work. If a first treatment does not help, that is information rather than failure, and the plan should be reviewed and adjusted. Support from family and friends measurably improves outcomes, provided it comes with clear boundaries and practical help. HealthLab’s depression section sets out how each condition presents, how it is assessed and what treatment involves — educational information, reviewed for accuracy, and designed to sit alongside professional care.